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Blood uric acid levels can increase during furosemide treatment, but precipitation of acute gout is rare. Furosemide may increase the toxic effect of aminoglycoside antibiotics on the ear, especially in patients with kidney dysfunction. Furosemide reduces the kidney excretion of lithium and can lead to lithium toxicity. Furosemide may impair kidney function when administered together with aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs). Periodic blood tests are performed to monitor kidney function and electrolytes during treatment with furosemide.
Drug Class and MechanismFurosemide is a potent diuretic (water pill). Furosemide works by blocking the absorption of salt and fluid in the kidney tubules, causing a profound increase in urine output (diuresis). The diuretic effect of furosemide can cause body water and electrolyte depletion. Therefore, careful medical supervision is necessary during treatment.
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Drug NameLasix (Furosemide)
Drug UsesFurosemide is a powerful diuretic. Furosemide is used to treat excessive fluid accumulation and swelling (edema) of the body caused by heart failure, cirrhosis, chronic kidney failure, and nephrotic syndrome. It is sometimes used in conjunction with other blood pressure pills to treat high blood pressure.
Possible Commonly observed side effects are low blood pressure, and water and electrolyte depletion. Less common side effects include jaundice, ringing in ears (tinnitus), light sensitivity, rash, pancreatitis, nausea, abdominal pain, dizziness, anemia, and other blood disorders.
Warnings/PrecautionsPatients allergic to sulfa may also be allergic to furosemide because of a similarity in the chemical structure of the medications. Furosemide should be avoided in kidney failure. Even though furosemide is important in treating excess fluid accumulation in patients with cirrhosis, sudden loss of fluid and electrolytes in these patients can worsen kidney function and even cause the patient to go into a coma. Furosemide can cause lowering of blood potassium, sodium, and magnesium levels. Low potassium and magnesium levels can lead to heart rhythm abnormalities, especially in patients already taking digoxin (Lanoxin). Please visit the digoxin (Lanoxin) site for further information.
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